Actress Marcia Cross spoke out this month about being diagnosed with a type of anal cancer caused by the human papillomavirus, which is better known as HPV.

Cross, 57, best known for her roles on television’s “Melrose Place,” “Knot’s Landing” and “Desperate Housewives,” was diagnosed last year during a routine exam by her gynecologist. She underwent chemotherapy and radiation and is now in remission.

Cross went on to reveal her husband, Tom Mahoney, was diagnosed with throat cancer in 2009 and also recovered. Doctors suspect both cancers stem from the same type of HPV, which the U.S. Centers for Disease Control said is so common nearly all men and women will get some form of the disease during their lifetime.

Nearly 80 million Americans are currently infected with the virus spreading through intimate skin-to-skin contact.

“The virus can remain latent for years,” said Dr. Erik Interval, head of the new Allegheny Health Network Head & Neck Cancer Center at Allegheny General Hospital. “It’s not really understood why it gets reactivated, but it can get reactivated and in a very rare subset of patients, you can get cancer from it.”

Interval said even when people are exposed to HPV, not every gets infected.

“Then people who do, some people never develop a problem,” he said. “There are a bunch of subtypes of the virus and most are low risk meaning that they are unlikely to cause cancer.”

Interval said he’s seeing an uptick in men with throat cancer caused by HPV.

“In terms of actual numbers of people with cancer, it can be related, throat cancer is going to overtake the incidence of HPV related cervical cancer,” he said.

While some infections go away on their own, HPV is also proven to cause cervical cancer in women as well as cancer of the vagina, penis, anus and the back of the throat.

In 2017, the Journal Annals of Internal Medicine found oral HPV is increasing in men between the ages 18 to 69.

Actor Michael Douglas was also open about his bout with oral cancer caused by HPV.

Douglas first sought medical help in 2010 after experiencing a sore throat that wouldn’t go away. Eventually, he was diagnosed with a cancerous tumor at the base of his tongue. He underwent chemotherapy and radiation and is now cancer free.

Interval said the good news is HPV-related tumors are usually treatable.

“Generally, it’s more responsive to treatment than if it were not related to the HPV virus,” he said. “The survival rate for this can be 90 percent.”

In the United States, oral HPV is much more common in men as opposed to women and Interval said most patients come into his office complaining of a sore throat or ear pain.

More than 48,000 cases of oral cancer were diagnosed in the United States in 2016 alone. Once thought to be caused by smoking or drinking alcohol, oral cancers caused by HPV strains are on the rise.

In fact, new data from the CDC shows the fastest growing segment of newly diagnosed oral cancers are in young, nonsmokers.

Interval said while many cervical cancer cases have been detected early thanks to pap smears in recent decades, other cancers caused by the HPV virus are on the rise.

“It’s the same virus that causes cervical cancer but with pap smears and now the vaccine, cervical cancer is really on the decline,” Interval said.

He said the hope now is the HPV vaccine will eventually lead to a drop in other HPV related cancers.

That HPV vaccine, commonly known as Gardasil, is now recommended by the CDC for boys and girls starting as early as age 11. Vaccination is recommended for young men and women all the way into their early 20s.

Doctors vaccinate adolescents before they are exposed to HPV and before they are old enough to become sexually active, Interval said.

“We’re hoping that the Gardasil vaccine seems to be effective, that then hopefully, in a couple of decades, this will take care of itself,” he said. “There’s a lag effect where you get people vaccines and it takes time to see if it’s gonna work or not.”


Kristin Emery is a meteorologist at KDKA-TV in Pittsburgh, an O-R columnist, and writer for Total Health magazine and other publications. Kristin is a Washington native and a graduate of Washington High School and West Virginia University.

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